The pharmacological effects of Puhuang
Pharmacological effects For the cardiovascular system Purpurin extract enhances the contractile force of isolated hearts at low concentrations and inhibits them at high concentrations. The heart rate of isolated hearts of rabbits and guinea pigs can be slowed down. When the dose is higher, the heart is restrained and stopped in the diastolic phase. Puertine alcohol extracts that are slightly less than the amount of myocardial inhibition can increase the coronary flow of isolated rabbit hearts without fibrillation or electrical stimulation to fibrillation by 35% and 43%, respectively. After the injection of pituitrin to contraction of coronary artery, the effect of Puhuang is more obvious, coronary flow can increase 76%. Fetal arterial injection of phthaloginol extract 0.03g (crude drug) / kg can increase blood flow to the femoral artery in anesthetized dogs, and the average peripheral resistance coefficient decreases by 62.7%. 6-amino purine is one of the active ingredients to reduce the peripheral resistance. In the case of constant perfusion of the femoral arteries in the whole dog, the femoral arterial injection of 0.05 to 10/15 kg of cationized resin and 1.0 to 10 to 15 kg of femoral vein injection resulted in an average reduction of 30.9% and 38.9% in hindlimb vascular resistance in anesthetized dogs, respectively. , Which believe that the cationic resin treatment part has the effect of reducing the hind-limb vascular resistance of anesthetized dogs. Puhuang extract also has an expansion effect on rabbit ear vessels. Intravenous injection of Puhuang decoction, alcohol extract and cation resin can all reduce the blood pressure and heart rate of anesthetized cats, rabbits and dogs, and inject atropine or hexamethylene bromide to block M-cholinergic receptors or nerves. After the festival, Puhuang's blood pressure, slowing down the heart rate and reducing the vascular resistance of the hind limbs were partially or completely eliminated. Reduce blood lipids and prevent atherosclerosis Animal experiments show that Puhuang has a role in lowering serum cholesterol and seems to play a role in inhibiting the formation of atherosclerotic plaque. Puhuang can prevent blood cholesterol levels in high-fat fed animals from increasing. The effect of Puhuang on cholesterol export from rabbit biliary tract shows that oral administration of Puhuang has the effect of anti-feeding hypercholesterolemia and inhibits the excretion of cholesterol from the biliary tract. The experimental results suggest that Puhuang's anti-feeding hypercholesterolemia is achieved by inhibiting the absorption of cholesterol and/or bile cholesterol in the food from the intestine, rather than by increasing the output of cholesterol. Observing the effect of Puhuang on prostaglandin metabolism in rabbits with experimental atherosclerosis (As), the results showed that Puhuang can not only effectively inhibit the formation of hypercholesterolemia in rabbits, but also increase plasma 6 - Keto-PGF1α levels, although Puhuang can not inhibit platelet aggregation, but also can not reduce plasma MDA levels, but As lesions significantly reduced. The study found that Puhuang water extract and its compound Xiaoxiao Powder promote fibrinolysis, indicating that it can directly decompose fibrin, does not depend on the presence of plasmin system. The active ingredients that promote fibrinolysis may be low molecular substances. After experimental oral jugular thrombosis in rabbits, the thrombolytic rate was significantly increased at 24 hours; there was no significant change in plasma fibrinogen and plasma plasminogen content; The dissolution activity is significantly enhanced within 2 to 5 hours of taking the drug. Effect on smooth muscle Puhuang decoction, expectorant and ether extracts showed excitatory effects on isolated uteri of guinea pigs, rats, and mice, and large doses could cause spastic contractions. Alcohol extract can make rabbits have pregnant rhythmic contraction of isolated uterus, so that pregnant women isolated from uterine tension. Puhuang on the unpregnant uterus than pregnant uterus has obvious effect, so that postpartum uterine contractility to strengthen or tension increased. The test of anesthetized dogs and rabbits in the uterus and house rabbit uterine fistula showed that: Puhuang preparation intravenous injection is also excited about the role of the uterus. Puhuang injection has a significant effect on the induction of guinea pigs and mice in the middle term. The minimum effective dose for intraperitoneal injection is 2~3g/kg. Puhuang extract can enhance the peristalsis of isolated rabbits; it can increase the tension of isolated duodenum in rabbits, rats and guinea pigs, and strengthen the rhythm contraction; but it can be blocked by atropine. The isorhamnetin contained in Puhuang has antispasmodic effect on isolated intestine of mice, and its intensity is 57% of papaverine. Procoagulant effect In vitro experiments showed that: Puhuang decoction has a procoagulant effect on human blood. Puhuang aqueous infusion or 5% ethanol infusion is given to rabbits, all of which can significantly shorten the clotting time. 10% decoction gavage rabbits, also has a role in shortening the time of blood clotting, especially after the first day of treatment. Health Puhuang oral, can shorten the clotting time of rabbits and the time of the mice's hemostasis; if baked orally, the effect is more enhanced than raw materials. Puhuang extract is administered subcutaneously to rabbits to increase the number of platelets and shorten the prothrombin time. Puhuang powder is used on wound surface to stop hemostasis in experimental femoral artery bleeding in anesthetized dogs. Some people think that isorhamnetin contained in Puhuang is an active ingredient for coagulation and hemostasis. Anti-inflammatory effect Puhuang decoction concentrated external application, the rats have obvious swelling effect on lower extremity burns, can also increase the rate of dissipation of rabbits in the skin Evans blue. Puhuang water decoction and alcohol precipitation preparations were given to rats by intraperitoneal injection, which had a certain swelling effect on egg white swollen feet, and could reduce the increase of vascular permeability caused by local injection of histamine in mice. It has been reported that the principle of swelling of Puhuang is to improve the local circulation, promote reabsorption and reduce the permeability of capillaries. Other effects 1:100 Puhuang preparation inhibited the growth of Mycobacterium tuberculosis in vitro. 100% decoction is given to subcutaneously inoculated guinea pigs with tubercle bacillus and has a certain therapeutic effect. Pueraria alcohol extract intravenously, has a certain gallbladder effect on anesthetized dogs. Lung Function Instrument Mouthpiece Lung Function Instrument Mouthpiece,Plastic Disposable Mouthpiece,Medical Paper Mouthpieces,Disposable Paper Mouthpieces Hengshui Qifei Paper Products Co. LTD , https://www.hengshuiqifei.com