Chinese researchers have discovered a new mechanism of liver iron damage
Researchers at Zhejiang University have found that iron levels are too high and hereditary hemochromatosis can cause "iron death" in liver cells and macrophages. At the same time, "cystine glutamate transporter" can inhibit liver iron death. The discovery will provide new ideas for liver iron damage and prevention of hemochromatosis. Related papers were published online in the international academic journal "Hepatology" on the 14th, and were jointly completed by Zhejiang University School of Public Health, Zhejiang University Institute of Translational Medicine and Zhengzhou University. "Iron death is a cell death pathway different from traditional cell death such as apoptosis and necrosis." Wang Fuzhen, a co-author of the paper and a professor at the School of Public Health of Zhejiang University, said that iron is the most abundant trace element in the human body and is widely distributed in various In tissues and organs. Iron death is mainly caused by iron-dependent oxidative damage, involving a complex series of biochemical reactions, gene expression and signaling. Taking hereditary hemochromatosis as an example, excessive iron is stored in substantial cells such as the liver, heart and pancreas, which eventually leads to tissue and organ disease, which is an important cause of chronic diseases such as liver disease, diabetes and heart disease. The incidence of hemochromatosis in European and American whites is extremely high, and it is the number one liver genetic disease. In China, the incidence of this disease has also increased year by year. Automatic Cable Reel,Automatic Water Hose Reel,Industrial Water Hose Reel,Automatic Garden Hose Reel NINGBO QIKAI ENVIRONMENTAL TECHNOLOGY CO.,LTD , https://www.water-hose-reel.com