Can replace expensive antibody therapy, this new vaccine is expected to prevent Alzheimer's disease
Release date: 2017-10-27 The new vaccine was discovered by a research team led by Dr. John Foerster of Dundee University and Professor Martin Bachmann of Oxford University. Related papers were published online October 31 in the journal Nature Npj Vaccines. Researchers are currently conducting clinical trials of the vaccine and have received regulatory approval. The emergence of new vaccines is based on the reality that monoclonal antibodies are widely used to treat non-infectious diseases, but they are expensive. Vaccines can provide a lower cost alternative, however, due to non-optimal T cell stimulation or weak vaccine response, vaccines are not effective in older patients. Artificial CMV virus-like particle vaccine structure Effective for chronic inflammatory diseases In this study, the team found that the repetitive structure of virus-like particles allows therapeutic vaccines to effectively bypass their tolerance. They combine the protein structure of the cucumber mosaic virus coat protein with the protein structure of the tetanus vaccine to stimulate the immune system and create vaccines for a variety of chronic diseases. The team tested a series of such vaccines for chronic inflammatory diseases (psoriasis, antigen: interleukin-17), neurodegenerative diseases (senile dementia, antigen: beta-amyloid), and allergic diseases ( The effects of cat allergy and antigen Fel-d1) showed positive results and increased antibody levels. These vaccines can both prevent or prevent diseases such as Alzheimer's disease and cure diseases like psoriasis. More research is needed to test the clinical efficacy of this treatment, but the study raises the possibility of tens of thousands of people suffering from chronic diseases. The principle of alternative antibody therapy Dr. Foerster said: "As a dermatologist interested in the immune system, I pay special attention to the vaccine against chronic skin diseases. The idea is simple - the latest and most effective on the market for diseases like psoriasis or eczema. The drug is called an antibody, just like me, you are dealing with bacteria in the common cold." He said: "For chronic diseases, these antibodies are tailor-made for the body's own proteins. By blocking this protein, the disease can heal. For example, in psoriasis, the development of the disease requires a protein called interleukin-17. So it is also possible to make the disease better by creating a vaccine that stimulates the body to produce antibodies against IL-17 itself. We can replace the need to inject expensive antibodies frequently, making this type of treatment more affordable, and Can be obtained for patients who cannot afford special antibodies." The advantages and prospects of the new vaccine Currently, antibodies to psoriasis treatment usually require at least one injection per month, and each patient in the UK costs about 10,000 pounds per year. And this new vaccine will provide more affordable treatment. In Alzheimer's disease, it is known that beta amyloid causes brain damage, which leads to inhibition of brain function. In previously unsuccessful trials, patients were injected directly with antibodies against the same target; new studies have shown that starting treatment in the form of a prophylactic vaccine provides a treatment even before clinical symptoms appear. Although scientists in the United States and Australia have jointly developed the first combined vaccine against Alzheimer's disease in July 2016, the older version of the vaccine was first reported. In principle, the vaccine is expected to have a more pronounced effect. Professor Bachmann said: "Alzheimer's disease usually occurs in the elderly. Therefore, this vaccine is optimized for the elderly, which seems to be particularly helpful. Another important aspect of the current work is that we developed a A platform technology, current preclinical research is expanding to vaccines for Parkinson's disease and chronic pain." Reference material 1) Incorporation of tetanus-epitope intovirus-like particles achieves vaccine responses even in older recipients inmodels of psoriasis, Alzheimer's and cat allergy 2) Vaccinating against psoriasis, allergies and Alzheimer's a possibility, research shows Source: Bio-Exploration (micro-signal biodiscover) Led Flood Light Camera,Solar Lights Outdoor Camera,Outdoor Led Flood Light,Flood Light Camera Wifi Shenzhen Zuomi Technology Co., Ltd. , https://www.bkvis.com