Scientists 3D print ovarian implanted mice successfully conceived
A few days ago, scientists at Northwestern University used a 3D printer to create an artificial ovary and implanted it into a mouse whose original ovary had been removed. The mouse was later conceived. The researchers published the results of the study at the Endocrinology Annual Meeting ENDO 2016 on April 2, 2016. Researchers hope to use the technology to develop an ovarian bioprosthesis and implant it into women to restore their fertility. It is understood that this technology may benefit those who have developed cancer in childhood and eventually survived, because statistics show that these people are at increased risk of infertility when they grow up. It is estimated that one out of every 250 adults is a survivor of childhood cancer. “One of the biggest problems facing cancer patients is that treatment may have an impact on their fertility and hormone health.†Dr. Monica M. Laronda, the lead author of the study and a postdoctoral fellow at Northwestern University's Feinberg School of Medicine, said: “We are developing A new approach to restoring their quality of life through ovarian bioprosthetic implants." The researchers used a 3D printer to print a biological scaffold to support hormone-producing cells and mature egg cells (ie, oocytes). This bioscaffold is supported by gelatin, a biomaterial derived from animal collagen. Scientists have adopted biological principles in the manufacture of the stent, which must be rigid enough to facilitate operation during surgery and provide sufficient space to support oocyte growth, angiogenesis and ovulation. When using human cell culture, the researchers determined that the optimal scaffold design should be criss-crossed so that cells can be held in multiple points. The scaffold is borrowed from follicles to produce a bioprosthesis. The so-called follicle is a spherical tissue with an oocyte in the middle surrounded by hormone-producing cells. To test the implant, the researchers removed the ovaries of the experimental mice and replaced them with ovarian bioprostheses. After that, the mice ovulate, give birth to healthy pups, and are able to maintain young cubs. In addition, mice implanted with ovarian bioprostheses also recovered estrus, or the estrogen cycle. To this end, researchers have come up with a theory that similar implants can help those who are born or have ovarian dysfunction due to disease treatment to maintain the hormone cycle. These women tend to experience reduced production of reproductive hormones, leading to problems during puberty and subsequent bone and vascular health problems. “We are using a scalable 3D printing method that uses materials that have already been used on the human body,†Laronda said. “We hope to one day repair female fertility caused by cancer treatment side effects or natural ovarian function defects. And hormone function problems." Scientists say the implanted scaffold structure supports the growth of blood vessels in mice, and they don't use anything to stimulate the process. Using a manufacturing technique inspired by human biology, researchers have developed a scaffold that interacts with human tissue. This technology is likely to play a role in the more complex soft tissue replacement in the future, Laronda said. Plant Extract,Mangiferin Extract Powder,Cordyceps Militaris Extract,Peppermint Leaf Extract Xi'an complex bio-tech CO.,LTD. , https://www.complexpowder.com