Huada Gene: Red is born in the world

This other person can't tell whether it is a "institution" of a scientific research institution, a state-owned company, or a private company. It has been able to grow and develop uniquely.

The Huada Gene, which later became a model of Shenzhen-style innovation, was born in Beijing at the end of the 20th century. It was born in Hong and has a national character gene.

The policies and financial support of governments at all levels have always played an indispensable role in the development of the gene. This other person can't tell whether it is a "institution" of a scientific research institution, a state-owned company, or a private company. It has been able to grow and develop uniquely.

Leaving the Chinese Academy of Sciences

In order to complete the 1% human genome sequencing task undertaken by China, at 9:09:09 on September 9, 1999, Beijing Huada Gene Research Center was announced in an old factory building in Beijing Airport Development Zone. "This time is not what we deliberately choose, it is God's will." Wang Jian said. According to media reports, in the process, the Chinese Academy of Sciences provided a building and a financial support of 4 million yuan.

Since the task of human genome sequencing was not a national decision at the beginning, but only the "personal behavior" of Wang Jian and other four people, Wang Jian was once called "abduction of the government." After several audits, Wang Jian and others succeeded in “cracking the system” and gained resources and honors. This has also become the consistent style of the cooperation between Huada Gene and the government since then: seeking policy and financial support from all levels of government, but it is always what the Huada Gene is leading.

In 2007, Wang Jian and others who did not meet the objectives of the Chinese Academy of Sciences decided to leave Beijing and go south to Shenzhen. At that time, Wang Jian predicted that with the advent of high-throughput sequencers, the gene sequencing market is about to break out, but the Chinese Academy of Sciences does not think so.

A person familiar with the matter told the Times Weekly reporter that the case of Huada Gene South was the result of the Shenzhen Municipal Government. Shenzhen is one of the first three bio-industry bases identified by the state. The bio-industry is also positioned by the Shenzhen Municipal Government as a strategic emerging industry. Today, the bio-industry has become the benchmark industry in Shenzhen. Shenzhen is good at finding samples, Mindray for medical devices, and Hai Purui for medicine are all successful model companies. In recent years, there are Shenzhen University in the field of stem cells and Huada Gene in the field of gene sequencing.

The official information released by Shenzhen shows that in 2012, Shenzhen's bio-industry achieved an output value of 91 billion yuan, ranking first among the national bio-industries.

In 2011, Tang Jie, deputy mayor of Shenzhen, said that when introducing the gene of China University, Shenzhen's support is to promise 20 million yuan per year for three years.

The decisive moment appeared in 2010. Shenzhen City promoted the National Bank to give Huada Gene a loan amount of 1.5 billion US dollars. Using 600 million yuan, Huada Gene purchased 128 sets of sequencer Hiseq2000 from Illumina and became the world's largest gene sequencing organization. This is also Illumina's largest order to date. Previously, Huada Gene had more than 20 sequencers.

In 2009, the income of Huada Gene was more than 50 million yuan. By 2010, its revenue exceeded 1 billion yuan.

However, Wang Jian said in 2012 that the support of state funds in 2011 accounted for more than 10% of the total investment of Huada, and in 2012 it was not even 10%.

Huada Technology was once the most important source of income for Huada Gene. “A paper on Nature can bring me 100 million yuan in cash income. We call this a circular economy.” Wang Jian once said, Huada Genes are not a business model, but a new development model. Providing genetic testing services to various universities and institutions, and publishing the fame and fortune of the papers, which makes Huada Gene known as "Foxconn in the biological world."

But Shenzhen’s support for Huada’s genes has never stopped, and every time it seems strong and vital.

The power of Shenzhen

The Shenzhen Municipal Government has always attached great importance to guiding the integration of production, education and research, from the 2009 Shenzhen Bio-industry Revitalization Development Plan (2009-2015) and the Shenzhen Bio-Industry Revitalization Development Policy, to the 2011 Shenzhen Gene Production and Research Fund. Alliance, industry transformation ability has always been placed in an important position.

In 2013, Shenzhen provided subsidies for non-invasive prenatal genetic screening for the first time in the country.

Shenzhen draws on the international medical management system and combines American experience with Chinese characteristics in non-invasive prenatal genetic screening and detection technologies. The US CLIA certification allows scientific research institutions that are qualified to be supervised by government departments to conduct advanced tests on advanced genetic testing technologies. Amniocentesis is commonly used in China. Shenzhen combines the two regulations, the public decides whether to do genetic testing, but whether to terminate the pregnancy must be amniocentesis and based on the results. In 2013, Shenzhen also established a non-invasive prenatal genetic testing industry research fund.

Similar policy ideas have been extended to the 2013 East Coast International Bio Valley planned by Shenzhen. Tang Jie said that Shenzhen has planned a 50-square-kilometer area in the eastern coastal Dapeng, Yantian and Pingshan areas to build an international bio-industry base – one of the important projects is the new headquarters of Huada Gene.

In 2015, Huada Gene was built into the National Gene Bank. It is China's first national-level gene bank. It is built and operated by Huada Gene. It is expected to store 30 million copies of biological samples by the end of 2015. The goal is to use genes in the future. The capacity and data quality of information exceeds the international three major gene databases (NCBI, UK EBI, Japan DDBJ).

At the beginning of July 2014, Shenzhen Mayor Xu Qin hosted a conference to study the industrialization of Huada's genes. In August, Xu Qin once again presided over the meeting, special research and coordinated promotion of the ten major projects of Huada's genetic sequencer industrialization. At this meeting, Xu Qin emphasized that the introduction and support of the development of Huada's genes, "is the municipal party committee The major decision made by the government requires Shenzhen to promote the “tangible hand” of the government and the “invisible hand” of the market, the benign interaction between the national science and technology plan and local supporting support, scientific research and development and the transformation of results, and fully support and promote the Huada gene. .

However, the eager expectations and positive policies of local governments for enterprises do not mean that technology must be mature and safe. Wang Xianming, director of the Department of Breast Surgery of the Second People's Hospital of Shenzhen, told the media in early 2015 that genetic testing is not mature enough in China. The domestic genetic sequences are now directly used in the country. “Europe and the United States have done large-scale clinical research, confirming that there are 5-10%. People have malignant tumor susceptibility genes, but there are not many Chinese people, and there is no evidence-based medical basis."

But this is not the most important consideration for BGI, and research and business are the things that Huada is most concerned about. As a 50-year-old towed by dreams, Wang Jian hopes to achieve technological breakthroughs quickly, especially after all of Huada’s genes have acquired CG.

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