Accurate medical inversion diagnosis: anemia female gene detection found misdiagnosis for 40 years

A 40-year-old woman was diagnosed with severe thalassemia and thrombocytopenia from a young age. Later, she was removed from the spleen and long-term use of drugs that inhibit platelet function. Further, the whole exon gene was sequenced, and the real pathogenesis machine was discovered. The change is due to a mutation in the gene associated with the endoplasmic reticulum of the cell, causing "an abnormal anaemia of congenital erythropoiesis". Transfusion treatment of thalassemia is countered.

The attached hospital of China Medical University officially opened the "precision medical clinic" on the 7th. Zhang Jianguo, deputy dean of China's medical doctors, pointed out that this is also the first Taiwanese application of 20,000 exon gene detection in outpatient diagnosis and treatment, which is difficult to diagnose and treat. Patients with genetic, rare diseases, cancer recurrence, and poor cancer treatment are expected to provide more precise treatment directions.

Zhang Jianguo also took the case of this patient as an example. He pointed out that this patient was diagnosed with severe thalassemia and thrombocytopenia due to anemia. He also was treated with alleviation of platelet function due to resection of the spleen and long-term use of drugs that inhibit platelet function. Subgenome sequencing, the results show that too many platelets are caused by misjudgment caused by red blood cell debris, the real pathogenesis is caused by mutations in the endoplasmic reticulum-related genes, and it is therefore recommended that the attending physician change the direction of treatment.

精准医疗翻转诊断:贫血女基因检测发现误诊40年

Zhang Jianguo pointed out that as early as 2013, Chinese medical doctors began to develop tests on genetic bodies. In August 2015, the research planning of precision medicine became one of the most important directions, and invested a lot of money and manpower. Under the active participation of all the physicians in the hospital, on the one hand, the core technology of precision medicine, genetic sequencing and biological information analysis system were established, and on the one hand, the genome test analysis of various difficult diseases was carried out. At the same time, in order to serve more patients, the clinical application-level genomic testing department came into being. This is approved by the American Clinical Pathology Laboratory (CAP) and is a rare exome sequencing certification in China. Passed inspection department.

China's doctors set up a precision medicine clinic, and it is also the first in Taiwan to apply precision medicine to outpatient diagnosis and treatment. In the future, it will systematically provide more comprehensive medical care for patients. It includes one-stop service from detection, bioinformatics analysis, verification to interpretation. All procedures are completed in the hospital, and 20,000 genes are detected to diagnose cancer, rare diseases and various genetic diseases.

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