New body immune system can accurately identify cancer antigens
Recently, a research report published in the international magazine Oncotarget, researchers from the University of Birmingham and the University of Virginia identified a new mechanism through which T cells may effectively distinguish between cancer cells. A class of targets with increased specificity, the authors focus on how the body's immune system recognizes protein targets modified by phosphorylation. Phosphorylation is a common process often seen in cancer cells. Phosphorylation plays a key role in the development of cellular signaling pathways. Special kinases add small phosphorylated groups to specific amino acid groups in proteins, and when phosphorylation is widely recognized as capable of controlling a range of cellular signals At the critical time of the pathway (including the role of regulating cell division), the researchers found that such pathways may become severely abnormally regulated in cancer. Previous studies by researchers have found that such phosphorylated protein fragments may appear on the surface of cancer cells to help with immune recognition. However, this small modification process affects the way T cells recognize cancer cells. The researchers are not clear in this study. Researchers have made some progress in this regard. Dr. Daniel Stones said that we have found through research that phosphorylation seems to play an important role in the recognition of cancer-associated targets by T cells. First, the results show that phosphorylation can induce significant changes in the overall structure of peptide proteins. Second, T cell receptors can very sensitively distinguish modified Peptides from unmodified peptide proteins, even When this induced change is small in scale. Active Pharmaceutical Ingredients Active Pharmaceutical Ingredients,Pregabalin,Sildenafil,Tadalafil Shaanxi Hongbaiyi Biotech Co., Ltd. , https://www.sxhongbaiyi.com