Photodynamic therapy accelerates the diagnosis and treatment of various human diseases
Photodynamic therapy accelerates the diagnosis and treatment of various human diseases October 25, 2016 Source: Bio Valley Photodynamic Therapy (PDT) is a new technology that uses photodynamic effects for disease diagnosis and treatment. The new technology is based on photodynamic effects. The advantages of photodynamic therapy are different from traditional surgery, radiotherapy and chemotherapy. They are selective for target tissues and damage, and can reduce the damage effect on normal tissues. Compared to other technologies, photodynamic therapy has the advantages of less trauma, low toxicity, and good selectivity. In recent years, scientists have made great progress in the use of photodynamic therapy to treat a variety of human diseases. In this article, Xiaobian has carried out an inventory and studied with you. [1] Chinese and American scientists discover a new way of cancer treatment---microwave-induced photodynamic therapy Doi:10.1166/jbn.2016.2322 In a new study, researchers from the Guangdong Provincial Key Laboratory of Orthopaedics and Implant Materials, Beijing University of Aeronautics and Astronautics and the University of Texas at Arlington found that the use of microwaves to activate photosensitive nanoparticles produces tissue heating effects. This ultimately leads to cell death in solid tumors. The results of the study were published in the October 2016 issue of the Journal of Biomedical Nanotechnology , entitled "A New Modality for Cancer Treatment - Nanoparticle Mediated Microwave Induced Photodynamic Therapy". Wei Chen, a professor of physics at the University of Texas at Arlington, said, "Our approach uses microwaves to penetrate all types of tissues and deeply target tumors located in them." Photodynamic therapy kills cancer cells by introducing light-sensitive nanoparticles into the tumor tissue, which then produces toxic singlet oxygen under light irradiation, while singlet oxygen is a highly active oxygen type that irreversibly damages the cell mitochondria. And eventually lead to cell death. [2] Photoimmunotherapy: laser-guided anti-cancer artifact On March 10, Aspyrian Therapeutics, a cancer treatment company in San Diego, USA, received $40 million in Series B financing. The current round of financing was led by Hiroshi Mikitani, the Japanese Internet giant and CEO of Lotte Co., Ltd. Coincidentally, the inventor of Aspyrian's core technology is also a Japanese. He is now a scientist at NCI, Hisataka Kobayashi. Jiulong Xiaolin believes that the current mainstream methods of treating cancer (surgery, radiotherapy/chemotherapy) are too harmful to the human body, while antibody treatments that are relatively less harmful to the human body, due to the large doses used during the treatment, have many side effects. It is also unbearable. Therefore, he has been wondering how to cure cancer while minimizing the harm of drugs to the human body. Of course, other scientists think so. In 2010, Jiulong Xiaolin’s wish was finally realized. Their team invented a new treatment for cancer, photoimmunotherapy. This therapy is described in their own language: precise targeted therapy. In November 2011, the innovative technology of the Jiulong Xiaolin research team was published in Nature Medicine. [3] Domestic new monomer porphyrin photodynamic drugs have completed phase III clinical trials A new type of photodynamic drug, Hembofen, for injection is expected to emerge in the field of treatment of port wine stains. The drug is a national new class drug jointly developed by Shanghai Fudan Zhangjiang Biomedical Co., Ltd. and the Chinese People's Liberation Army General Hospital. It is a new monomeric porphyrin photodynamic drug and has completed Phase III clinical trials. Its structure is clear, metabolism is rapid, it can be quickly removed from tissues, its toxicity to normal tissues is very low, and the acute and long-term toxicity are lower than that of the first generation photodynamic drugs hematoporphyrin derivatives. Early treatment with port wine stains uses surgical skin grafting, isotope, freezing, etc., which can damage the skin and cause scarring. In recent years, the use of pulsed dye laser treatment has a significant effect on thin lesions of the vascular layer, but it is not ideal for large-area and heavier lesions, and there are defects such as inadvertent operation, scarring and recurrence. Photodynamic therapy is a new method for the treatment of port wine stains. It is a new disease treatment method based on the interaction of light, photodynamic drugs and oxygen. Photodynamic drugs are injected into the vascular endothelium of the lesion site after intravenous injection. The cells are rapidly absorbed, and after being irradiated with light of a specific wavelength, cytotoxic substances are generated in an aerobic environment, so that the expanded and deformed capillary network is selectively destroyed, and the influence on normal tissues is small. Compared with traditional treatment methods, photodynamic therapy has the advantages of rapid onset, uniform lesion regression, high cure rate, low incidence of scar, and difficulty in recurrence. However, in the past, photodynamic drugs such as hematoporphyrin derivatives have been excreted slowly in the body due to complex components, and patients have to be strictly protected from light for more than one month after treatment, which brings great inconvenience to patients' lives and limits their limitations. The clinical application of this method. [4] JCO: New therapy can kill up to 95% of cancer cells with a single dose and a beam of light A new, non-invasive treatment that kills up to 95% of cancer cells in just two hours with a single dose and a beam of light. The newly patented method of killing cancer cells was developed by Matthew Gdovin, associate professor of biology at the University of Texas at San Antonio (UTSA). This finding may greatly help cancer patients who cannot be surgically removed or whose medications are difficult to reach the site of the tumor, as well as young children with cancer. The relevant research results were recently published in the Journal of Clinical Oncology, entitled "Photodynamic acidification therapy to reduce triple negative breast cancer growth in vivo". Gdovin's first-class research involved injecting a compound, nitrobenzaldehyde, into tumor tissue and allowing it to spread there. He then applied a beam of light to the tumor, causing the tumor cells to have a strong intracellular acidity inside the tissue and thus commit suicide. Within two hours, Gdovin estimates that up to 95% of cancer cells die. "Although there are many different types of cancer, they are similar because their sensitivity to this acidity induces cancer cells to commit suicide," he said. [5] Nat Med: Using photons to develop photodynamic therapy for deep cancer Doi: 10.1038/nm.2933 Researchers at the National University of Singapore have found that a new technology promises to lay the groundwork for a new safe and non-invasive approach to treating in-depth cancer. Under the leadership of Associate Professor Zhang Yong, the team has so far demonstrated that in mice, their technology can inhibit tumor growth and control gene expression. This is the first time in the world to use nanoparticles to develop non-invasive photodynamic therapy for the treatment of advanced cancer. Related research results were recently published online in the journal Nature Medicine. The team found a way to control gene expression using nanoparticles that convert near-infrared light into visible or ultraviolet light. These nanoparticles can be introduced into the patient's target site to perform their function. In our body, genes express certain proteins in order to ensure that our internal “complexes†function properly and that we remain healthy. However, this process can sometimes be biased and cause our body function to malfunction, leading to different diseases. But doctors use ultraviolet light to manipulate the gene expression process to correct this bias. However, ultraviolet light may cause more harm than good. Associate Professor Zhang said, "Near-infrared light can penetrate deeper into our tissues in addition to being non-toxic. When near-infrared light reaches a specific position in the patient's body, we develop nanoparticles that convert near-infrared light into ultraviolet light. Light (up-conversion) to effectively activate genes in a specific way, ie to control the amount of each protein expression, when and how long it lasts." [6] Multi-point flowering Concordia for photodynamic anticancer therapy Original link: Concordia running trials to expand use of its laser-activated cancer-fighting drug Cancer is one of the biggest health problems facing humans. Today, scientists still find it difficult to find an effective way to treat these diseases. One of the important reasons is that tumor cells are cancerous from healthy cells of patients, and current anticancer therapies are difficult to distinguish them from healthy tissue cells. This has prompted many scientists to research new treatments to cope with this problem. Recently, Concordia Healthcare, a biopharmaceutical company from Canada, began research on photodynamic anticancer therapies. The therapy developed by the company is based on a targeted therapeutic regimen of photosensitizer. Patients receive a dye containing photosensitizer and an invasive laser generator prior to treatment. This dye can be specifically inserted into the tumor tissue area. After 40-50 hours of injection, the laser emitted by the laser emitter activates these dyes, transforming them into cytotoxic substances, leading to tumor cell death. At the same time, these dyes can also destroy blood vessels in the tumor site and may stimulate the immune system to enter the area to help kill tumor cells. Photofrin has been approved by the FDA for the treatment of tumor types such as esophageal cancer and non-small cell lung cancer. [7]EBM: Fluorescence monitoring wine stain photodynamic therapy effect and prognosis It has been known in the past that the therapeutic effects of using photodynamic therapy (PDT) vary greatly from patient to patient and are related to the concentration of light-sensitive substances in the irradiated tissue. Wang et al., published in February 2010, Experimental Biology and Medicine (Experimental Biology and Medicine) The journal's research establishes a fluorescence analysis method that not only quantifies the concentration of light-sensitive substances, but also predicts the efficacy of photodynamic therapy for wine stains (PWS). A concentration of light-sensitive substances can be calculated by researchers in the Department of Laser Medicine of the General Hospital of the Chinese People's Liberation Army. The concentration of the concentration-time curve can be used to estimate the therapeutic effect-related index (TECI) when performing photodynamic therapy. The correlation between TCI and PDT treatment outcomes was assessed using 31 PWS patients at the Chinese People's Liberation Army General Hospital. [8] Early cervical cancer photodynamic therapy is beneficial to the retention of fertility In recent years, the number of patients with cervical atypical hyperplasia and carcinoma in situ has gradually increased, while young female patients need to retain fertility. Studies have shown that cervical conization is associated with obstetrical risks, such as premature birth. Sakamoto et al used photodynamic therapy to treat 520 patients with early cervical lesions. The results showed that 95% of patients had complete remission (CR). The CR rates of patients with atypical hyperplasia, squamous cell carcinoma and microinvasive squamous cell carcinoma were 99%, 97% and 92%, respectively. Retrospective analysis showed that although photodynamic therapy and cervical conization were the same, the pregnancy rate and yield were significantly increased after the former treatment. In addition, the early labor rate after photodynamic therapy was also significantly lower than that of conization. The cumulative yield curve of photodynamic therapy was significantly higher than that of conization. SARS-CoV-2 Neutralizing Antibody Test Cassette SARS-CoV-2 Neutralizing antibody Test Cassette NINGBO AUTRENDS INTERNATIONAL TRADE CO., LTD , https://www.metests.com