U.S. Use of Genetically Modified Eggs to Produce Human Monoclonal Antibodies

US genetic engineering experts announced on August 29th that scientists have jointly used stem cell technology and transgenic technology to produce fully functional human monoclonal antibodies from eggs for the first time. The researchers said that this breakthrough is expected to dramatically increase the production efficiency of monoclonal antibody drugs and reduce costs. The above-mentioned research results jointly obtained by scientists from Orijin Pharmaceuticals, Texas Agricultural University, and University of California, Los Angeles were published in the recently published "Natural Biotechnology" magazine. The researchers said that they first implanted the gene encoding the human monoclonal antibody into chicken embryonic stem cells, and also implanted a gene code that controls the monoclonal anti-aggregation site so that the monoclonal antibody can only exist in the egg protein, and then Transgenic embryonic stem cells are implanted into chicken embryos. Chickens hatched in this way can produce eggs containing human monoclonal antibodies after 8 months. The researchers said that the gene encoding the human monoclonal antibody is expressed in the fallopian tubes of chickens, and the resulting antibodies are only found in egg proteins. Each egg contains 1-3 mg of antibody and is easily purified. The characteristics of monoclonal antibodies carried by eggs are almost the same as those produced by traditional methods, but the ability to kill cells is 10 to 100 times higher.

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