Product Advantages and Applications of USphereTM Ultrasound Microbubble Contrast Agent
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USphereTM Prime
Through its good contrast stability, it can also be applied to more complex industrial applications.
Excellent contrast imaging solution
USphereTM Prime is a microbubble developer designed for small animal ultrasound. It has a very small microbubble particle size and a wide range of resonant frequencies, which can be effectively applied to high-resolution ultrasound and current general medical ultrasound systems, providing excellent contrast image quality depending on the context of use.
Suitable for high resolution ultrasound
The USphereTM series has the smallest particle size distribution among current commercial products. Its special particle size distribution makes its resonance frequency very wide. Based on this feature, Prime is your best choice for high-resolution ultrasound imaging and related algorithm development!
Low dose , longer aging
Based on our core technology, USphereTM Prime provides longer in vivo cycle times compared to existing clinical products at lower doses. The researcher is allowed to flexibly perform the contrast procedure, perform multiple injections and contrasts in one day, and collect complete physiological information of the experimental animals.
Stable and consistently suspended
In addition to good performance in live experiments, the USphereTM Prime's good stability and suspension characteristics make some acoustic studies possible, such as: ultrasonic sound field scanning and water flow state analysis. This is not possible with generally too large microbubbles.
USphereTM Tracer is an advanced developer that is coated with fluorescent light.
It can be used as a simulated drug to evaluate the results of ultrasound drug delivery, or to observe its flow characteristics in a living body directly in a fluorescent imaging system.
Use fluorescent light to expand your research
USphereTM Tracer is a fluorescently modified microbubble developer. Researchers can use fluorescent images to track the distribution of these bubbles in the body, assist in verifying the target position of the target image, or use the coated fluorescent molecules to simulate the drug release of the ultrasound. In some physiological studies, fluorescent images can also be used to observe the state of bubbles flowing in a specific vascular network.
Same SPECT quality as Prime
USphereTM Tracer has the same key features as Prime, including:
·Applicable to existing clinical ultrasound and small animal high resolution ultrasound.
· Has a very wide resonant frequency.
• Even at lower doses, it provides longer aging than existing clinical products.
· With good stability and suspension capacity, it can be maintained for at least one hour under flow and dilution.
Different fluorescent bands
USphereTM Tracer offers two fluorescent bands for researchers to choose from.
Tracer - Green, whose main absorption and emission wavelengths are as follows: Ex* 484 nm; Em* 501 nm.
· Tracer - Red, whose main absorption and emission wavelengths are as follows: Ex* 549 nm ; Em * 565 nm .
Researchers can make choices based on context.
Application Examples
· Repeated confirmation by fluorescent section in the study of target images
·Used as a simulated drug or positioning on a live fluorescing system (IVIS)
· Observe the release process of ultrasound drugs and related biological effects in living organisms
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USphereTM Labeler is a developer designed for target imaging with Biotin on the surface, allowing researchers to freely bond to the desired target molecule or antibody.
Use fluorescent light to expand your research freedom to create target developers
USphereTM Labeler is an advanced developer that provides biotin (Biotin) for modification on the surface. By modifying different target molecules, the researchers can target angiography for different diseases such as tumor, inflammation, and even embolization, so that the ultrasound reaches the level of molecular imaging.
Same SPECT quality as Prime
USphereTM Labeler has the same key features as Prime, including:
·Applicable to existing clinical ultrasound and small animal high resolution ultrasound.
· Has a very wide resonant frequency.
• Even at lower doses, it provides longer aging than existing clinical products.
· With good stability and suspension capacity, it can be maintained for at least one hour under flow and dilution.
The simplest way to modify the creature
USphereTM Labeler has been modified on the surface by Biotin to form a link with Avidin, and further allows researchers to modify biotinylated target molecules on Labeler. This modification is currently the fastest and simple modification. Use only 15 to 30 minutes at room temperature to complete the modification!
* Please contact us if you need other modification options.
Applications
· Modify antibodies such as anti-VEGFR2 to observe tumor angiogenesis
· Evaluate the degree of endovascular embolization or increase the efficiency of thrombolysis through the target
· Conduct research on target treatment to allow drugs or genes to accumulate on tumors
USphereTM Trans+ is a developer designed for target imaging with biotin modified on the surface, allowing researchers to freely bond to the desired target molecule or antibody.
Make gene delivery easier
Ultrasonic gene transfer is one of the most suitable gene transfer patterns for living organisms. Trans+ is further designed to carry genetic factors using microbubbles, using positively charged lipid molecules to adsorb genes. It is no longer complicated to transfer ultrasound genes.
Same SPECT quality as Prime
According to previous studies, it is generally believed that microbubbles with positive surface charge can be used to adsorb DNA and RNA molecules, thereby improving the efficiency of transfection in the application of ultrasonic gene transfer. In some special applications, bubbles with a positive surface charge can also be used to adsorb on the cell surface.
Adsorption of genetic factors by electrical properties
USphereTM Labeler has been modified on the surface by Biotin to form a link with Avidin, and further allows researchers to modify biotinylated target molecules on Labeler. This modification is currently the fastest and simple modification. Use only 15 to 30 minutes at room temperature to complete the modification! * Please contact us if you need other modification options.
Applications
· Use acoustic perforation to increase stem cell transfer efficiency
· Rapidly obtain a large number of transgenic cells
·Easy to achieve the study of living gene transfer
· Use genes for cancer treatment
The ResonarTM range is an economical package of USphereTM Prime that offers the same tiny particle size and excellent contrast quality as Prime.
For related product features and benefits, please refer to the introduction of USphereTM Prime.
Smaller packaging can also help researchers continue to use the currently activated microbubbles in small but continuous studies, further reducing variation and increasing experimental stability. ResonarTM will be your best choice for a series of experiments!