Talking about mobile medical intelligent hardware: non-invasive blood glucose meter (2)
In the last chapter, we introduced the evolution direction of non-invasive blood glucose meters based on technology. However, many technologies are not commercially available due to engineering and cost issues. Therefore, in this chapter, we will introduce the latest products in the world with products as the axis. Trend products and R&D companies, together with readers, sort out the full picture of this market. After the news of Google's development of blood glucose monitoring contact lenses, it has received great attention from the industry. This contact lens has tens of thousands of tiny transistors and an antenna that is thinner than the hairline. It can monitor the blood sugar level of the wearer's tears and send it to the mobile device such as a smartphone in a wireless form. Go to the pain of taking blood tests. Microsoft is not to be outdone. Desney Tan, a researcher at Microsoft Research, said: "Microsoft started the glucose-sensing contact lens project in 2011 and worked with Brian Otis, who previously worked for the Google Glass Project. Cooperative research and development." Otis is one of the leaders of Google's smart contact lens project. The technical orientation of the two top companies in the industry is the same, but the specific details of the products are rarely disclosed and need to be tracked continuously. NovioSense of the Netherlands is also developing a similar in-eye sensor product that can detect intraocular glucose levels remotely. The product will undergo the first phase of clinical trials this year (2014) and there are currently no more publicly available materials. OrSense, Israel, is testing a non-invasive monitoring system based on spectroscopic technology called "SpectOLight", which uses a non-invasive light measurement platform with a ring finger sensor. The ring sensor gives the finger pressure to temporarily block the blood flow, forming a new blood power, which produces a unique light signal, which can be measured by analyzing these signals. At present, the accuracy rate is said to be up to 90%, and there are reports that the previous clinical trials are better and the accuracy is higher. However, there are reports that the technique is not stable: some patients with type 1 diabetes and patients with high blood sugar fluctuations have large deviations. Based on the principle of iontophoresis technology, Medtronic developed the MiniMed non-invasive blood glucose meter, which is worn on the arm to continuously measure the patient's blood glucose reading. If the user has symptoms of hypoglycemia, they will receive an audible and visual signal. At present, Dekang Medical is also carrying out a similar industrialization layout, and the capital market is very hot and its market value soars. However, he is mainly based on subcutaneous implant technology. In the future, long-term application may still need to replace the plant and replace the battery, etc., and the time interval is shorter, and the fingertip blood collection is required to be calibrated twice, so it is not strictly speaking. Non-invasive blood glucose measurement, so this article is no longer developed, but Dr.2 believes that continuous monitoring is definitely a trend, and is very optimistic about Dekang's technical direction. GlucoWatch developed by Cygnus Medical Instruments, California. GlucoWatch looks like an electronic watch and is slightly larger than a regular electronic watch. It can be used to determine the patient's immediate blood sugar status. However, some users said that when the current flows from the skin, it feels a little painful, and sometimes there are some malfunctions, and the product picture is also old. It is said that in foreign countries, watch-type blood glucose meters have been put into practical use. In March 2001, it was approved by the US FDA for blood glucose measurement in children. According to reports, the watch-type blood glucose meter can provide relatively accurate measurement values. Dr.2 was introduced by Professor Fu Xiaosheng from Fudan University in 2003. He contacted the company and wanted to represent this product to match the hot oral insulin project. Collaborate. However, in that year, it was acquired by a company without the following. However, this is the first non-invasive blood glucose meter test approved by the FDA in history, so it needs to be highlighted. How it works: The back of the watch-type blood glucose meter passes through a layer of gel pad (gel, a form of matter between solid and liquid, does not flow like a liquid, but can be dissolved in different sizes Molecules, passing under the action of an electric field.) Contact with human skin. There are two electrodes in the gel, and the circuit is turned on when used, generating a small amount of current through the skin of the human body. The charged ions in the skin move to the positive and negative electrodes respectively under the action of current, and the glucose molecules in the tissue fluid are "sandwiched" together by the charged ions to enter the gel. The watch type blood glucose meter can calculate the current blood sugar level by measuring the degree of reaction between the glucose molecule and an enzyme (glucose oxidase) in the gel, and the measurement result is displayed on the "watch" screen. Functional oligosaccharides refer to oligosaccharides that are difficult or impossible to be digested and absorbed by the human body and have special physiological effects on the human body. Its sweetness is generally only 30-50% of that of sucrose, and it has physiological functions such as low-calorie, anti-caries, prevention and treatment of diabetes, and improvement of intestinal colony structure. Due to the special physiological functions of functional oligosaccharides, it becomes a nutrient and health care product. A new generation of food-effect raw materials that integrate diet and therapy. It is a new functional sugar source that replaces sucrose and has a wide range of uses and application prospects. Common functional oligosaccharides include: xylo-oligosaccharides, fructooligosaccharides, galacto-oligosaccharides, isomaltose, raffinose and so on. XOS, GOS, FOS, IMO, Raffinose, oligosaccharide Xi'an Gawen Biotechnology Co., Ltd , https://www.ahualynbio.com
