Are you choosing the medium for culturing mesenchymal stem cells?

Mesenchymal stem cell therapy will become the mainstream of stem cell new era! Is your medium selected correctly?

Stem cell therapy, also known as regenerative medicine, refers to the repair of tissues that use stem cells and their derivatives to promote damage, pathology, or loss of function. Today, many patients such as leukemia have benefited from stem cell therapy. In the future, osteoarthritis, cerebral palsy, heart failure, multiple sclerosis, and even hearing loss are expected to benefit.

Stem cell therapy is at the forefront of life sciences and will lead to a new medical revolution. "After 10 to 20 years, stem cells will become a basic treatment technology to help people solve diseases that cannot be overcome now." Deng Hongkui, a professor at Peking University's School of Life Sciences, has received a lot of attention. Many patients think that 10 to 20 years are too long, and hope that stem cells can help humans overcome the pain caused by disease.

Stem cell research is developing rapidly, and mesenchymal stem cells are becoming mainstream

Nowadays, a large number of new research, new projects and new therapies have emerged in the global stem cell therapy market, most of which are in the research and development pipeline, and a few have been approved by the regulatory authorities.

The ongoing research on cord blood stem cells, bone marrow stem cells, skin stem cells, and placental stem cells for the treatment of cardiovascular diseases and diabetes will open a new door for market development.

NIH's ClinicalTrials is the world's largest clinical trial database. According to the statistics of this database, the clinical trials of mesenchymal stem cells have developed rapidly in recent years. From 2014 to 2016, the number of new clinical trials increased by about 100 per year, and 62 new ones were added in the first half of 2017, and hundreds of new ones are expected to be added throughout the year.

It has been found that clinical trials of mesenchymal stem cells involve hundreds of diseases. Nervous system, cardiovascular and orthopedic diseases are the three main areas of research, accounting for more than 15% of the total, more than half of the total. In addition, the proportion of diabetes, liver, lung, gastrointestinal tract, skin and GVHD is about 5%, which is an important research direction of clinical application of mesenchymal stem cells.

Specifically, spinal cord injury, multiple sclerosis, stroke, amyotrophic lateral sclerosis, Alzheimer's disease, osteoarthritis, femoral head necrosis, disc degeneration, myocardial infarction, cirrhosis, Crohn's disease, interstitial lung disease Systemic lupus erythematosus, erectile dysfunction, and premature ovarian failure are more studied diseases. These patients are expected to benefit from mesenchymal stem cell therapy earlier.

At present, there are already approved mesenchymal stem cell therapeutic products in the world. According to statistics, more than 13 stem cell therapeutics have been marketed worldwide, most of which are mesenchymal stem cell products. With the development of clinical trials, more mesenchymal stem cell treatment products will be approved for marketing in the future, and more patients will benefit.

Mesenchymal stem cell serum-free medium, have you chosen the right one?

In recent years, with the progress of cell therapy, the interest in the in vitro culture of cells has also been increasing. As a cell product regulated by drugs, like all drugs, the evaluation standard is also "safety and effectiveness." Therefore, the culture medium for mesenchymal stem cells has become the core concern of enterprises and scientific research institutions that research and apply MSC cells.

There are many “serum-free” media on the market, ranging in price from 1000-4000. Make the user confused, I don't know why. In fact, the "serum-free" mesenchymal stem cell culture media on the market can be divided into three categories. The first is "fake serum-free" MSC medium; the second is "without clear-blooded serum-free" MSC medium; the third is "true serum-free" MSC medium.

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