A key mechanism for human muscle regeneration to uncover harmful accumulation of TDP-43 to form amyloid
A key mechanism for human muscle regeneration to uncover harmful accumulation of TDP-43 to form amyloid November 8, 2018 Source: Science and Technology Daily Author: Zhang Meng Ran A medical paper published online by the British journal Nature recently said that protein TDP-43 will accumulate during normal muscle growth and regeneration and play a functional role. TDP-43 is often associated with neuromuscular diseases such as amyotrophic lateral sclerosis (ALS) and is considered pathogenic. Scientists believe that increased muscle regeneration in the disease may lead to the harmful accumulation of this protein. Studies have shown that TDP-43 protein aggregates accumulate in the skeletal muscle of patients with neuromuscular diseases such as inclusion body myopathy. Decreasing TDP-43 levels leads to age-related muscle weakness in mice and Drosophila, suggesting that TDP-43 may play a functional role in muscle formation. This time, Roy Parker, Brad Orvin, and colleagues at the University of Colorado, Boulder, studied the function of TDP-43 during normal mammalian skeletal muscle formation. They found that TDP-43 is abundant in mouse muscle cells and increases during skeletal muscle cell formation. Hereditary consumption of TDP-43 prevents cell growth and leads to cell death, suggesting that the protein plays an important functional role in muscle regeneration. In addition, the research team also reported that during the growth of mouse muscle cells, TDP-43 protein will aggregate to form a more complex structure - "muscle - granules", which can be converted to amyloid structure over time. However, it is usually cleared in mature cells with normal function. Biopsy results from patients with muscle weakness confirmed the persistence of muscle-particles in the regenerative muscle. Researchers believe that sustained muscle regeneration in neuromuscular disease may increase the level of TDP-43 and prevent the production of muscle-particles, which may lead to the development of pathogenic amyloid in diseased muscles, and age-related Sex factors may increase the risk of this shift. Co2 Fire Extinguisher,Portable Co2 Fire Extinguisher,Carbon Dioxide Fire Extinguisher,Co2 Extinguisher Nanjing Txfire International Trade Co., Ltd , https://www.txfireequipment.com