A cell protective enzyme regulates human tuberculosis pathology

A cell protective enzyme regulates human tuberculosis pathology

November 20, 2018 Source: Science and Technology Daily

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Heme oxygenase-1 (HO-1) is a cytoprotective enzyme that controls the inflammatory response and redox homeostasis, but its role in the pathogenesis of tuberculosis (TB) remains unclear. Krishna Goda and colleagues at the Department of Microbiology, Faculty of Medicine, University of Alabama at the University of Alabama, USA, examined the role of heme oxygenase-1 in tuberculosis cells and pathology using newly excised human tuberculosis lung tissue. . Flow cytometry and histopathological analysis showed that heme oxygenase-1 was mainly expressed in bone marrow cells, and the concentration level was directly proportional to cell protection. Heme oxygenase-1 reduces the pathophysiology of tuberculosis by reducing bone marrow cell-mediated oxidative damage caused by reactive oxygen or nitrogen intermediates, which control granulocyte nucleus rupture to produce heme oxygenase -1 partition reaction. Using systemic or bone marrow-specific heme oxygenase-1 deficient mice, the researchers demonstrated that heme oxygenase-1 is a substance necessary to control bone marrow cell infiltration and inflammation to prevent progression of tuberculosis. This new study suggests that the partitioning of heme oxygenase-1 in bone marrow cells can regulate the immunopathology of human tuberculosis.

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