Latest research: Immunotherapy is expected to treat AIDS

Latest research: Immunotherapy is expected to treat AIDS

November 15, 2016 Source: Xinhua News Agency

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In recent years, immunotherapy to treat cancer has become a hot topic. But a new study published in the New England Journal of Medicine shows that the treatment is also expected to be used to treat even functional cures.

Researchers at institutions such as the University of Pennsylvania have injected a broad-spectrum neutralizing antibody called VRC01 into 24 HIV carriers. It has been shown to safely induce the immune system to produce large amounts of this antibody, which is appropriately delayed after discontinuation. The time of the HIV rebound. The downside is that this virus inhibits the body in most subjects for up to 8 weeks.

Pablo Trobas, director of the University of Pennsylvania Clinical Trials Center, who is in charge of the study, said in a statement that the study used only one antibody and they believe that immunotherapy combined with more powerful antibodies may help to effectively control HIV. "We are unlikely to completely eradicate a person's HIV infection in the near future, but functional cure is a reasonable intermediate goal."

Functional cure of AIDS means that after the HIV carriers stop treatment, although there are still a small amount of virus in the body, the virus is completely inhibited and cannot be detected, and the body functions normally.

However, the study also found that HIV in many subjects is inherently resistant to broad-spectrum neutralizing antibodies, which may be a barrier to antibody-based immunotherapy for AIDS.

To date, the use and spread of antiretroviral therapy has greatly extended the lives of people living with HIV, but this treatment cannot cure AIDS. Antiretroviral drugs need to be taken once a day, many people can't persist for a long time, and the virus usually rebounds quickly after stopping the drug.

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