Cell: The necessary genetic map of cancer cells can be drawn by means of CRISPR
Cancer is a heterogeneous disease with many subtypes caused by different genetic roots. Therefore, the multiple pathways on which cancer survives depend on the response to anticancer drugs. The challenge for researchers is to precisely define these different pathways and point out loopholes that can serve as targets for new anticancer therapeutics. Researchers at the Whitehead Institute and the Broad Institute in the United States have taken an important step in addressing this challenge: they have successfully identified cancer cell proliferation and survival in the 14 acute myeloid leukemia cell lines that were previously sequenced. Important genes. Combining maps of essential genes with existing genomic information, their research shows that cancer subclassification through gene definition can be used to develop new therapies. The study was published online on February 2nd, entitled "Gene Essentiality Profiling Reveals Gene Networks and SyntheticLethal Interactions with Oncogenic Ras." The network necessary to define Ras-specific genes Important aspects of the research focus on the genes and protein pathways associated with the oncogene Ras. Ras is the most common mutant oncogene in acute myeloid leukemia and other human cancers. Tim Wang, the first author of the article, explains: “In most cases, the mutated Ras protein itself is considered to be 'no cure.' Another way is to find other genes for Ras-mutated cancers, hopefully they will work. Medications. Such 'Ras Synthetic Lethal' genes were previously very difficult to discern." Based on CRISPR gene editing technology, researchers can measure the effects of knocking out 18,000 human genomic protein-encoding genes alone. The synthetic lethal partner gene of the oncogene Ras was discovered by comparing Ras-dependent and non-dependent cell lines. Corresponding author David Sabatini explains: "This process allows us to quickly identify the list of genes that are selectively required in Ras mutant cells. We believe this versatile approach can find loopholes in many cancer types." Manual Massage Collapsible Foot Spa Massager The Manual Massage Foldable Foot Spa Massager is a portable compact device designed to give your feet a relaxing massage experience. Its foldable design makes it easy to store and transport, making it ideal for the frequent traveler. Manual Massage Collapsible Foot Spa Massager,Foot Bath Massager Machine,Electric Heated Foot Spa,Foot Bath Tub Huaian Mimir Electric Appliance Co., LTD , https://www.footspamachine.com
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