Japanese research team discovered some mechanisms of cancer immune evasion
Release date: 2016-05-25 According to a report by the Kyodo News Agency on May 24, research teams such as Kyoto University and the University of Tokyo published research results in the British scientific journal Nature on the 24th, saying that some mechanisms for cancer cells to escape the immune system attack were discovered. If an abnormality occurs in a specific domain of a cancer cell gene, the attack power of the immune system is reduced. Xiaochuan Cheng, a professor of Peking University oncology at the research team, said: "After investigating whether there is an abnormality in this domain, it is possible to try to know in advance whether the anticancer drugs that prevent the immune system from stopping should be effective." The research team used supercomputers to analyze the genetic information of about 10,000 cancer cell samples. In some data such as lung cancer, gastric cancer, esophageal cancer and colorectal cancer, the common domains of these cancer cell genes were found to have common abnormalities. Happening. Once this domain is abnormal, the protein called "PD-L1" will become active, and the role of the immune T cell surface protein "PD-1" will be weakened, thus evading immune system attacks. In the experiment, the research team implanted abnormal cancer cells in specific domains into mice, and the cancer cells were shrunk after using anticancer drugs that did not stop the immune system from attacking. Source: World Wide Web Electrical Fire Monitoring System Electrical Fire Monitoring System,Electrical Fire Monitoring Detector,Combined Fire Monitoring Detector,Combined Electrical Fire Detector LIAONING YINGKOU TIANCHENG FIRE PROTECTION EQUIPMENT CO.,LTD , https://www.tcfiretech.com