Genomic rearrangement system promotes yeast strain evolution
Release date: 2018-05-23 The British "Nature News" magazine released a series of latest achievements in the international cooperation program of Sc2.0 (Eukaryotic Yeast Artificial Gene Combination) on the 22nd: multinational scientists applied the genome rearrangement system (SCRaMbLE) to the synthetic chromosome of yeast, speeding up Yeast strain evolution. Recent advances in these synthetic biotechnologies will not only advance the process of human drug synthesis, but will further strengthen our ability to regulate and control life processes. Saccharomyces cerevisiae is the first eukaryotic organism to be sequenced by whole genome, but it needs to be modified to produce specific products or endure harsh industrial conditions. The so-called genomic rearrangement system (SCRaMbLE) aims to form a large amount of genetic diversity by rearranging genes on chromosomes. The resulting strain can then be screened according to the desired goal, such as improved product synthesis. For haploid yeast, if key genes are deleted, it may kill strains that might have been prolific. To solve this problem, the research team at the Longmani Medical Center at New York University has crossed yeast containing synthetic chromosomes with wild-type S. cerevisiae or a close relative of S. paradoxus. The diploid progeny thus obtained are more robust than the haploid strain and can grow at a high temperature of 42 ° C and high caffeine conditions. In another study, the Imperial College of England applied the SCRaMbLE system to a yeast strain carrying a fully synthetic chromosome V to improve drug synthesis and metabolize the yeast strain to another sugar source. The researchers added the biosynthetic pathway of penicillin to the yeast and processed the yeast genome using the SCRaMbLE system, which ultimately increased its productivity by a factor of two. They also promoted the growth of yeast strains using xylose through the SCRaMbLE system (xylose is widely present in plants). In 2012, China and the United States jointly promoted the Sc2.0 international cooperation program, and Chinese scientists artificially synthesized 4 of the 16 Saccharomyces cerevisiae chromosomes, accounting for 66.7% of the internationally completed number. The collection of a series of papers published by Nature·Communication is about the experimental results of redesigning the yeast genome. The accompanying review article confirms the potential application and impact of this progress on synthetic biology, biotechnology, and genomic cognition. . Source: Technology Daily Wearable Breast Pump,Breast Pump,Latex Free Breast Pump,Deep Expression Breast Pump NINGBO YOUHE MOTHER&BABY PRODUCTS CO.,LTD , https://www.oembreastpump.com