" Eat" to delay aging, human trials have made important progress | Nature Subsidiary
Release date: 2018-04-24 Image source: Nature Communications (doi:10.1038/s41467-018-03421-7) Scientists have long known that caloric restriction can resist physiological signals associated with aging. Numerous studies in fruit flies, nematodes, rodents, and even humans have shown that long-term reductions of about one-third of calorie intake can achieve a variety of health benefits, including extended lifespan. However, for many people, this diet control strategy is not easy to implement. After all, it is very difficult to "control your mouth." As a result, many research teams have been looking for ways to “replace†calorie restrictions, but still produce the same benefits. On March 29th, in a study published in Nature Communications entitled "Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults," scientists from the University of Colorado, Bouller School confirmed that When people eat a natural dietary supplement called “nicotinomide riboside†(NR) every day, they can also initiate the same chemical pathways associated with health benefits as calorie restriction. The study also found that supplementation with NR also helps improve blood pressure and arterial health, especially in people with mild hypertension. Professor Doug Seals, who led the study, said: "This is the first study to allow humans to take this novel compound. We have shown that NR is well tolerated and seems to activate the same biological pathways that calorie restriction can activate." Specifically, the study investigated 24 thin, healthy men and women between the ages of 55 and 79. Half of the participants took placebo for 6 weeks, followed by 500 mg of NR chloride (NIAGEN) twice a day; the other half took NR for 6 weeks followed by a placebo. The results of the analysis showed that taking 1000 mg of NR per day increased the level of a compound called NAD+ (nicotinamide adenine dinucleotide) in the participants by 60%. Previous studies have confirmed that NAD+ is required to activate sirtuins, a key enzyme involved in the health benefits of calorie restriction. (Sirtuins are involved in a series of metabolic activities in the body, but as they age, it gradually declines.) The study also found that in 13 participants with elevated blood pressure or stage 1 hypertension (120-139/80-89 mmHg), their systolic blood pressure decreased by about 10 points after NR supplementation. This decline in amplitude can translate into a 25% reduction in the risk of heart attack. The authors hope that in the future, NR supplements will be shown to reduce this effect of systolic blood pressure in larger clinical trials. They believe that compounds that mimic calorie restriction may become a new option for people whose blood pressure is not high enough to take medication but still have a heart attack risk. Christopher R. Martens, the first author and correspondent of the paper, said: "Although we are not sure whether this compound is safe and effective only for certain people, this paper has laid a very The important foundation." It is reported that Martens and Seals have applied for a grant for a larger clinical trial to investigate the effects of NR supplements on blood pressure and arterial health. In addition, Martens has initiated a separate trial to investigate the impact of supplemental NR on older people with mild cognitive impairment. Reference materials: Dietary supplement shows promise for reversing cardiovascular aging Source: Bio-Exploration
Respiratory products are the medical consumables widely used in the hospitals who need the oxygen therapies, include the oxygen mask, venturi mask, nasal cannula, nebulizer mask, aerosol mask, ambu bag., etc.
Respiratory products,Medical disposables for respiratory,Hospital consumables for respiratory,Respiratory devices 2 MEDS TECHONOLOGY CO.,LTD , https://www.2-meds.com