Worm/embryo flow sorting system - development and validation of high-throughput screening instruments for drug automation in zebrafish

Thanks to the development of genomics, combinatorial chemistry and high-throughput screening technology, the use of small molecular targets for drug screening research has made great progress. However, the drug screening method has a success rate of less than 3%, and the known target sites that can be studied are very limited. Therefore, finding a better drug model for drug detection and screening is one of the major issues that need to be addressed urgently. Some holistic organisms provide a good choice.
The advantage of drug-based screening methods based on organisms is based on the screening of compounds by intact individual organisms, rather than under artificially simulated conditions.
The zebrafish is small in size and the zebrafish embryos are transparent enough to meet the requirements of automated high-throughput screening. Zebrafish provides an ideal biological model for drug screening. The researchers in this paper developed the system Union Biometrica- Worm / Embrane Flow Sorting System, which is capable of high-throughput screening of compounds in vivo using zebrafish.
The researchers used zebrafish to validate two studies of cardiotoxicity testing and drug screening for angiogenesis inhibitors, which can be automated on the system platform. Effectively improve the success rate of drug screening.
The worm/embryo flow sorting system is produced by Union Biometrica, Inc., Massachusetts, USA, which is a world-renowned manufacturer of Worm / Embryo Sorter, dedicated to the research, design and manufacture of biological sorting systems.

Original link:Development and Validation of an Automated High-Throughput System for Zebrafish In Vivo Screenings

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