Hot Selling Pharmaceutical Raw Material Tianeptine Sodium CAS 30123-17-2
Food Grade Diacetate,Food Grade Sodium Diacetate,Sodium Diacetate,Sodium Diacetate C4H7Nao4 Wuxi Yangshan Biochemical Co.,Ltd. , https://www.yangshanchem.comQuick details
Product Name:
Tianeptine sodium salt
Synonyms:
TIANEPTINE SODIUM;TIANEPTINE SODIUM SALT;sodium 7-((3-chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoate s,s-dioxide;7-[(3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic Acid S,S-Dioxide Sodium Salt;S-1574;Stablon;7-[(3-chloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine-11-yl)amino]heptanoic acid s,s dioxide sodium salt;Sodium 7-((3-chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoate S,S-dioxide
CAS:
30123-17-2
MF:
C21H24ClN2NaO4S
MW:
458.93
EINECS:
250-059-3
Mol File:
30123-17-2.mol
 Description
Tianeptine (brand names Stablon, Coaxil, Tatinol, Tianeurax and Salymbra) is a drug used primarily in the treatment of major depressive disorder, although it may also be used to treat asthma or irritable bowel syndrome. Chemically it is a tricyclic antidepressant (TCA), but it has different pharmacological properties than typical TCAs as recent research suggests that tianeptine produces its antidepressant effects through indirect alteration of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity.
Tianeptine has antidepressant and anxiolytic (anti-anxiety) properties with a relative lack of sedative, anticholinergic and cardiovascular adverse effects,[citation needed] thus suggesting it is particularly suitable for use in the elderly and in those following alcohol withdrawal; such persons can be more sensitive to the adverse effects of psychotropic drugs. Recent results indicate possible anticonvulsant (anti-seizure) and analgesic (painkilling) activity of tianeptine via immediate or downstream modulation of adenosine A1 receptors (as the effects could be experimentally blocked by antagonists of this receptor).
Medical uses
Tianeptine shows efficacy against serious depressive episodes (major depression), comparable to amitriptyline, imipramine and fluoxetine, but with significantly fewer side effects. It was shown to be more effective than maprotiline in a group of people with co-existing depression and anxiety. Tianeptine also displays significant anxiolytic properties and is useful in treating a spectrum of anxiety disorders including panic disorder, as evidenced by a study in which those administered 35% CO2 gas (carbogen) on paroxetine or tianeptine therapy showed equivalent panic-blocking effects. Like many antidepressants (including bupropion, the selective serotonin reuptake inhibitors, the serotonin-norepinephrine reuptake inhibitors, moclobemide and numerous others) it may also have a beneficial effect on cognition in people with depression-induced cognitive dysfunction.
Tianeptine sodium
Compared to other TCAs it produces significantly fewer cardiovascular, anticholinergic (like dry mouth or constipation), sedative and appetite-stimulating effects. A recent review found that it was amongst the antidepressants most prone to causing hepatotoxicity (liver damage), although the evidence to support this concern was of limited quality. Although not well studied with tianeptine, it has been shown for tricyclic antidepressants that they may cause cardiac arrhythmias.
COA
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Product Name
Tianeptine sodium
Batch No.
160625
Mfg. date
2016-6-25
Test Date
2016-6-25
Exp. date
2018-6-24
Tests
Specifications
Results
Description
White to yellowish powder, very hygroscopic.
Off-white powder, very hygroscopic.
Solubility
Freetly soluble In water and methanol and dichloromethane
Complies
Identification
(1)By IR, To match with working standard
Complies
(2)It gives reaction of sodium
Complies
Impurities A
≤0.1%
Not detected
Related compounds
Any impurity ≤0.1%
<0.1%
Total impurities ≤0.4%
0.25%
Residual Solvents
Acetidin≤ 0.5%
Not detected
Dichloromethane≤ 0.06%
Not detected
Methanol≤ 0.3%
Not detected
Acetone ≤ 0.5%
Not detected
Acetonitrile≤0.041%
Not detected
Ethanol≤0.5%
0.04%
N, N-dimethylformamide≤0.088%
Not detected
Water
≤ 5.0%
1.38%
Assay
99.0%-101.0%(On anhydrous basis)
99.98%
Conclusion
Conform to EP8.0
Our advantage
1, High quality with competitive price:
1)Standard: Enterprise Standard
2)All Purity≥ 99%
3)We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1)Parcel can be sent out in 24 hours after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice.
3)Customs pass rate ≥ 99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
3, We have clients throughout the world.
1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
Â
Quick details
Product Name:
Tianeptine sodium salt
Synonyms:
TIANEPTINE SODIUM;TIANEPTINE SODIUM SALT;sodium 7-((3-chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoate s,s-dioxide;7-[(3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic Acid S,S-Dioxide Sodium Salt;S-1574;Stablon;7-[(3-chloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine-11-yl)amino]heptanoic acid s,s dioxide sodium salt;Sodium 7-((3-chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoate S,S-dioxide
CAS:
30123-17-2
MF:
C21H24ClN2NaO4S
MW:
458.93
EINECS:
250-059-3
Mol File:
30123-17-2.mol
 Description
Tianeptine (brand names Stablon, Coaxil, Tatinol, Tianeurax and Salymbra) is a drug used primarily in the treatment of major depressive disorder, although it may also be used to treat asthma or irritable bowel syndrome. Chemically it is a tricyclic antidepressant (TCA), but it has different pharmacological properties than typical TCAs as recent research suggests that tianeptine produces its antidepressant effects through indirect alteration of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity.
Tianeptine has antidepressant and anxiolytic (anti-anxiety) properties with a relative lack of sedative, anticholinergic and cardiovascular adverse effects,[citation needed] thus suggesting it is particularly suitable for use in the elderly and in those following alcohol withdrawal; such persons can be more sensitive to the adverse effects of psychotropic drugs. Recent results indicate possible anticonvulsant (anti-seizure) and analgesic (painkilling) activity of tianeptine via immediate or downstream modulation of adenosine A1 receptors (as the effects could be experimentally blocked by antagonists of this receptor).
Medical uses
Tianeptine shows efficacy against serious depressive episodes (major depression), comparable to amitriptyline, imipramine and fluoxetine, but with significantly fewer side effects. It was shown to be more effective than maprotiline in a group of people with co-existing depression and anxiety. Tianeptine also displays significant anxiolytic properties and is useful in treating a spectrum of anxiety disorders including panic disorder, as evidenced by a study in which those administered 35% CO2 gas (carbogen) on paroxetine or tianeptine therapy showed equivalent panic-blocking effects. Like many antidepressants (including bupropion, the selective serotonin reuptake inhibitors, the serotonin-norepinephrine reuptake inhibitors, moclobemide and numerous others) it may also have a beneficial effect on cognition in people with depression-induced cognitive dysfunction.
Tianeptine sodium
Compared to other TCAs it produces significantly fewer cardiovascular, anticholinergic (like dry mouth or constipation), sedative and appetite-stimulating effects. A recent review found that it was amongst the antidepressants most prone to causing hepatotoxicity (liver damage), although the evidence to support this concern was of limited quality. Although not well studied with tianeptine, it has been shown for tricyclic antidepressants that they may cause cardiac arrhythmias.
COA
Â
Product Name
Tianeptine sodium
Batch No.
160625
Mfg. date
2016-6-25
Test Date
2016-6-25
Exp. date
2018-6-24
Tests
Specifications
Results
Description
White to yellowish powder, very hygroscopic.
Off-white powder, very hygroscopic.
Solubility
Freetly soluble In water and methanol and dichloromethane
Complies
Identification
(1)By IR, To match with working standard
Complies
(2)It gives reaction of sodium
Complies
Impurities A
≤0.1%
Not detected
Related compounds
Any impurity ≤0.1%
<0.1%
Total impurities ≤0.4%
0.25%
Residual Solvents
Acetidin≤ 0.5%
Not detected
Dichloromethane≤ 0.06%
Not detected
Methanol≤ 0.3%
Not detected
Acetone ≤ 0.5%
Not detected
Acetonitrile≤0.041%
Not detected
Ethanol≤0.5%
0.04%
N, N-dimethylformamide≤0.088%
Not detected
Water
≤ 5.0%
1.38%
Assay
99.0%-101.0%(On anhydrous basis)
99.98%
Conclusion
Conform to EP8.0
Our advantage
1, High quality with competitive price:
1)Standard: Enterprise Standard
2)All Purity≥ 99%
3)We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1)Parcel can be sent out in 24 hours after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice.
3)Customs pass rate ≥ 99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
3, We have clients throughout the world.
1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
Â