Vacuum freeze dryer working principle

Vacuum freeze dryer working principle:

After the vacuum freeze-drying machine, the material is put into the material box for freezing. The freezing process of the material, on the one hand, the vacuum system is vacuumed to take away part of the water; on the other hand, the material is contained in certain molecules when it is frozen. The water is discharged to the surface of the material to freeze. After the freezing requirement is reached, the material is heated and dried by the heating system, and the water contained in the material is brought to the freezing and collecting box to be frozen by vacuuming to achieve the requirement of freezing and drying of the material.

A vacuum freeze dryer is a process that removes moisture or other solvents from a frozen biological product by sublimation. Sublimation refers to the process of solvents, such as water, like dry ice, which change from a solid to a gaseous state without going through a liquid state. The product obtained by freeze drying is referred to as a lyophilizate, and the process is referred to as lyophilization. Traditional drying can cause the material to shrink and damage the cells. The structure of the sample is not destroyed during the freeze drying process because the solid component is supported by the firm ice at its location. When the ice sublimes, it leaves pores in the dry remaining material. This preserves the biological and chemical structure of the product and the integrity of its activity. In the laboratory, lyophilization has many different uses and is indispensable in many biochemical and pharmaceutical applications. It is used to obtain biological materials that can be preserved for a long period of time, such as microbial culture, enzymes, blood, and pharmaceuticals, in addition to long-term preservation stability, retaining its inherent biological activity and structure. To this end, vacuum freeze dryer freeze-drying is used to prepare tissue samples for structural studies (eg, electron microscopy studies). Freeze drying is also used in chemical analysis to obtain dried samples or to concentrate samples to increase analytical sensitivity. Freeze-drying stabilizes the sample components without changing the chemical composition, making it an ideal analytical aid. Freeze drying can occur naturally. In the natural case, this process is slow and unpredictable. Through the freeze-drying system, people have improved and subdivided many steps to speed up the process.