Chinese scientists reveal the "developmental cell map" of the human digestive tract

Release date: 2018-05-28

How many cell types are there in the human digestive tract? What are they "long"? After years of joint research, Chinese scientists have comprehensively and systematically elucidated the gene expression map and signal regulation mechanism of esophage, stomach, small intestine and large intestine during human embryo development for the first time in the world. The field provides comprehensive, informative developmental cell map data.

The research results of the Beijing Future Gene Diagnosis Center (ICG), Peking University Biodynamic Optical Imaging Center and Peking University Third Hospital have been jointly researched and developed in the internationally renowned academic journal Nature and Cell Biology. 》Online published.

The digestive tract is the most important component of the human digestive system. It is mainly composed of the esophagus, stomach, small intestine and large intestine. It reveals the gene expression regulation network and "cell type map" of these four organs in human embryo development. It is a developmental organism. One of the major issues in the field of study.

"This study is the first in the world to fully and systematically reveal the precise developmental pathways and gene expression characteristics between different cell types of these four organs under single-cell resolution and whole transcriptome conditions." Professor Tang Fuyue, deputy director of the Beijing Center for Genetic Diagnosis, a single-cell functional genomics study of embryonic and germline development, said.

Source: Guangdong Daily

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