Chinese and American experts work together to develop new intelligent nano drugs to accurately combat brain tumors

On June 6th, the medical network has multiple physiological barriers in the brain tumor site. These barriers are like urban walls, blocking foreign drugs from entering brain tumor tissues. The reporter was informed on the 5th that the research team of Prof. Lu Weiyue from the School of Pharmacy of Fudan University cooperated with the research team of Professor Zhang Liangfang of the University of California, San Diego. After three years of hard work, he developed a new intelligent nano drug against brain tumors.
Lu Weiyue told reporters that smart nano drugs can remain stable in the blood circulation for a long time, "circumventing" the blood-brain tumor barrier, reaching the destination where the drug could not reach, that is, tumor tissue, introducing more drugs into brain tumors and in tumors. Released in the cell, a precise blow to the brain tumor. Lu Weiyue said that smart nano drugs have the characteristics of small toxic and side effects and high safety.
Supported by the National Major Scientific Research Program and the Shanghai Municipal Education Commission's major projects, the research results obtained by Chinese and American scholars are published online in the latest international authoritative academic journal, ACSNANO.
According to reports, there is a blood-brain barrier in the early stage of brain tumors. After the formation of new blood vessels in the tumor tissue, a blood-brain tumor barrier appears. They allow nutrients to enter brain tissue and brain tumor tissue, but they can be blocked as a rock. Foreign drugs enter. Lu Weiyue said that at present, brain tumor treatment is mainly through surgical resection, but because brain tumors occur in the central nervous system and the boundary is blurred, it is difficult to completely remove the surgery; postoperative drug treatment is hindered by physiological barrier, the treatment effect is not good and it is easy to cause brain tumor recurrence. However, simply increasing the dose of chemotherapy will bring serious side effects, which will eventually lead to poor treatment compliance.
In order to solve the problem that drugs are difficult to "collect" the blood-brain tumor barrier, Lu Weiyue's research team and Zhang Liangfang's research team have cooperated and explored for many years, and decided to use high-loaded nanocrystalline technology, long-circulating cell membrane coating technology and lesions. The combination of targeted techniques for tissue navigation has finally led to the development of a new intelligent nanomedicine that can be used in the treatment of brain tumors.
How does smart nanomedicine work? Scientists first prepared chemotherapeutic drugs into nanocrystals, and then mixed them with erythrocyte membranes equipped with active navigation functional molecules. Active navigation of erythrocyte membranes became "disguise", and related components became "passports" for the body's blood system, avoiding being treated as "foreign matter" is cleared. The "camouflage coat" has excellent targeting and enhances the distribution of drugs in the tissues and cells of the lesion. It is reported that this intelligent nano-drug can also reduce the systemic distribution of drugs, which is conducive to improving the safety of drug treatment and reducing the incidence of side effects.
Lu Weiyue said that the technology can effectively inhibit brain tumor growth by a single high-dose intravenous injection, and the preparation method and raw materials are simple, which is beneficial to industrialization. Zhang Liangfang revealed that the equipment used for blood transfusion can obtain erythrocyte membrane materials, and the in vitro blood cell culture technology also helps to promote the clinical transformation of this technology.

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